منابع مشابه
The role of insulin and leptin in male reproduction
In recent years, the incidences of obesity, diabetes mellitus and male factor infertility have increased in the general population. Obesity, which can lead to metabolic syndrome, is characterized by elevated leptin levels; diabetes mellitus is characterized by decreased insulin levels or insulin insensitivity. A large body of evidence suggests that insulin and leptin play a role in the physiolo...
متن کاملImplications of leptin in neuroendocrine regulation of male reproduction.
Obesity is a major health problem contributing to increased subfertility in males, as well as increased morbidity for diseases related to a decline in testosterone production with aging. Leptin is a hormone produced by adipose tissue whose production increases with the amount of body fat. Several studies have supported a relationship between increased leptin production and regulation of reprodu...
متن کاملLeptin and reproduction.
Leptin, a hormone secreted from adipose tissue, plays an important role in reproductive physiology. It has been shown to stimulate the reproductive system by rescuing the sterility of leptin-deficient mice and advancing the onset of puberty in normal mice. Although leptin is not critical for the biology of pregnancy in mice, its ability to reduce food intake is blunted in mid-gestation suggesti...
متن کاملLeptin and reproduction.
Fertility in mammals requires adequate nutrition and a certain reserve of metabolic fuel (Van Der Spuy, 1985). Individuals experiencing wasting diseases (e.g. insulin-dependent diabetes), severe dietary restriction (e.g. anorexics), or who are high-performance athletes (e.g. marathon runners or ballet dancers) may have severely impaired reproductive systems (De Souza & Metzger, 1991; Stewart, 1...
متن کاملLeptin in reproduction.
PURPOSE OF REVIEW Leptin, a key hormone in energy homeostasis and neuroendocrine function, has a permissive role in initiating puberty and is crucial in the pathogenesis of reproductive dysfunction in several disease states of energy imbalance. KiSS1 neurons have recently been suggested to mediate leptin's effect on the reproductive system. New insights from recent animal studies and clinical t...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Reproduction
سال: 2019
ISSN: 2305-0500
DOI: 10.4103/2305-0500.268143